OpenGL is a graphics API created by The Khronos Group. It's designed to primarily to be used on desktop systems, alongside counterparts such as OpenGL ES targeting mobile devices or WebGL for websites.
Drivers are included in media-libs/mesa and cannot be removed since it's integral to the system.
- Xorg/Hardware_3D_acceleration_guide — a guide to getting 3D acceleration working using the DRM with Xorg in Gentoo.
- OpenCL — a framework for writing programs that execute across heterogeneous computing platforms (CPUs, GPUs, DSPs, FPGAs, ASICs, etc.).
- Vulkan — a next-generation graphics API created by The Khronos Group.