USB Power Saving

Linux has the ability to power off USB devices and to let USB device requests to wake them up again.

It is important to note many optical mice do not support power saving. Once they lose power power they cannot detect motion and cannot power back on when motion is invoked. With this being stated, it is possible to use specific driver calls or the sysfs file to enable or disable auto-suspend for individual USB peripherals.

Configuration
Set auto suspend to 1 second:

Enforce for every device: