Wine

Wine(Wine Is Not an Emulator) is an application that allows Windows software to run on Linux. This article deals with installing, configuring and maintaining a general purpose Wine environment on Gentoo.

Installation
Enable the USE flags of choice and emerge :

Media
Generally want your Wine environment to support as much media as possible so the recommendation is to enable as many of the following USE flag.

Miscellaneous
It seems that an error will occur if USE="win64" is added. So USE="win64" is not recommended.

Prevent wine from adding menu entries and desktop links
To delete already added menu entries you have to delete the corresponding files from ~/.local/share/applications

Debugging
If you find a bug and want to file a bug report you'll probably be asked to try the latest version, and if you are not running testing, you'll need to un-keyword it:

Now when you update it you should make sure the custom-cflags USE flag is enabled, as debugging will be impossible without it.

Links

 * Wine Homepage