Wine

Wine(Wine Is Not an Emulator) is an application that allows Windows software to run on Linux. This article deals with installing, configuring and maintaining a general purpose Wine environment on Gentoo.

Installation
Enable the USE flags of choice and emerge :

Media
Generally want your Wine environment to support as much media as possible so the recommendation is to enable as many of the following USE flag.

Debugging
If you find a bug and want to file a bug report you'll probably be asked to try the latest version, and if you are not running testing, you'll need to un-keyword it:

Now when you update it you should make sure the custom-cflags USE flag is enabled, as debugging will be impossible without it.

Links

 * Wine Homepage